Objective To study the effect of early plastic repair on wound healing of burn patients. Methods A total of 80 burn patients admitted to our hospital from August 2018 to August 2022 were selected as the research objects. They were divided into control group (n =41) and study group (n =39) by random number table method. The control group was treated with conventional plastic repair, and the study group was treated with early plastic repair. The treatment efficacy, wound healing index, inflammatory factor level, pain score at each time point and secondary operation rate were compared between the two groups. Results The total effective rate of treatment in the study group was 97.44%, which was higher than 80.49% in the control group (P <0.05). The wound healing time and wound skin blood supply recovery time in the study group were shorter than those in the control group (P <0.05). After treatment, IL-1, IL-6 and TNF-α in the study group were lower than those in the control group (P <0.05). The pain score of 6, 12 and 24 h after treatment in the study group was lower than that in the control group (P <0.05). The secondary operation rate of the study group was 2.56%, which was lower than 17.07% of the control group (P <0.05). Conclusion Early plastic repair for burn patients can improve the clinical efficacy, accelerate wound healing, improve wound blood supply, relieve inflammatory reaction and pain, improve the quality of life of patients, and reduce the rate of secondary surgery.