: Objective:Exploring the nursing effect of comprehensive nursing intervention in eye plastic surgery. Methods: 300 patients who underwent eye plastic surgery from May 2022 to March 2024 were randomly divided into two groups, with 150 patients in each group. The control group received routine nursing care, while the observation group received comprehensive nursing intervention. Compare the effects of two intervention groups. Results: After the intervention, the score of operation effect and nursing satisfaction in the observation group were higher than those in the control group, and the total incidence of complications, SAS and SDS were lower than those in the control group (P < 0.05).Conclusion: The application of comprehensive nursing intervention in patients undergoing eye plastic surgery has been proved to be effective, which can significantly improve their physical and mental health, ensure the surgical effect and reduce the incidence of postoperative complications. This nursing mode is safe and helpful to improve patients" satisfaction with nursing service.