Facial skin rejuvenation is a hot topic in the field of clinical practice and cosmetology. In view of the trauma of surgical treatment, a variety of non-surgical treatment methods have received extensive attention. Among them, fractional laser is a kind of laser therapy, which can be divided into ablative fractional laser and nonablative fractional laser. The application of fractional laser alone or in combination with other treatment methods is effective and has a good application prospect. This article reviews the research progress of different types of fractional laser therapy in facial skin rejuvenation, in order to provide more comprehensive and effective medical cosmetic services for patients with the demand of facial skin rejuvenation.