Objective To explore the effect and safety of micro-implant anchorage in orthodontic treatment. Methods A total of 50 patients who underwent orthodontics in our hospital from June 2018 to June 2021 were randomly divided intoconventional group and experimental group, with 25 patientsin each group. The conventional group was treated with extraoral archreinforced anchorage for orthodontic treatment, and the experimental group was treated with micro-implant anchorage for orthodontic treatment. The clinical efficacy, oral health status and psychological status of the two groups were compared. Results The total effective rate of treatment in the experimental group was 96.67%, which was higher than 80.00% in the conventional group (P <0.05). The plaque index and gingival bleeding index of the experimental group were lower than those of the conventional group (P <0.05). The SAS and SDS scores of the experimental group were lower than those of the conventional group (P <0.05). Conclusion The application of micro-implant anchorage in orthodontic treatment is effective. Compared with theextraoral archreinforced anchorage, the orthodontic effect is better, which is conducive to promoting the recovery of oral health and improving the psychological status of patients.