外用1%西替利嗪溶液治疗男性雄激素性秃发的临床疗效观察
作者:
作者简介:

阮振强(1987.11-),男,山东德州人,硕士,主治医师,主要从事常见皮肤病诊疗、毛发疾病、医务管理等工作

通讯作者:

于德宝(1973.9-),男,山东潍坊人,硕士,主任医师,主要从事医院管理及皮肤外科、皮肤疮疡性疾病诊治工作

中图分类号:

R758.71

基金项目:

山东省医务职工科技创新计划联合立项项目(编号:SDYWZGKCJHLH202220)


Clinical Effect of 1% Cetirizine Hydrochloride Drops for External Use in the Treatment of Male Androgenetic Alopecia
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    摘要:

    目的 探讨外用1%西替利嗪滴剂治疗男性雄激素性秃发的临床效果及安全性。方法 选择2022年 9月-2023年8月在济南市皮肤病防治院就诊的64例男性雄激素性秃发患者为研究对象,根据随机数字表法分 成对照组与观察组,每组32例。对照组外用5%米诺地尔搽剂,观察组外用1%盐酸西替利嗪滴剂,比较两组 临床疗效、毛发总密度、视觉主观评分及不良反应发生情况。结果 观察组治疗后总有效率为81.25%,略低 于对照组的90.63%,但差异无统计学意义(P>0.05);两组开始用药3、6个月后毛发总密度均高于开始用药 前,但观察组开始用药3、6个月后毛发总密度低于对照组(P<0.05);两组开始用药3个月后视觉主观评分 比较,差异无统计学意义(P>0.05);观察组开始用药6个月后视觉主观评分低于对照组(P <0.05);两组 用药后均未出现明显、严重不良反应。结论 1%西替利嗪滴剂治疗男性雄激素性秃发的效果肯定,可提高 毛发总密度,改善头皮毛发视觉效果,是治疗AGA的一种新选择,且具有良好的安全性。

    Abstract:

    Objective To investigate the clinical efficacy and safety of 1% cetirizine hydrochloride drops in the treatment of male androgenetic alopecia. Methods A total of 64 male patients with androgenetic alopecia who were treated in Jinan City Hospital for Skin Disease Prevention and Treatment from September 2022 to August 2023 were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 32 patients in each group. The control group was treated with 5% minoxidil liniment, and the observation group was treated with 1% cetirizine hydrochloride drops. The clinical efficacy, visual subjective score, total hair density and adverse reactions were compared between the two groups. Results The total effective rate of the observation group after treatment was 81.25%, which was slightly lower than 90.63% of the control group, but the difference was not statistically significant (P >0.05). The total hair density of the two groups after 3 and 6 months of treatment was higher than that before treatment, but the total hair density of the observation group after 3and 6 months of treatment was lower than that of the control group (P <0.05). There was no statistically significant difference in the visual subjective scores of the two groups when comparing them 3 months of medication (P >0.05). The visual subjective score of the observation group was lower than that of the control group after 6 months of medication (P <0.05). There were no obvious and serious adverse reactions in the two groups after treatment. Conclusion 1% cetirizine hydrochloride drops is effective in the treatment of male androgenetic alopecia, which can increase the total hair density and the visual effect of scalp hair. It is a new choice for the treatment of AGA and has good safety.

    参考文献
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阮振强,景 鸣,刘 鸣,等.外用1%西替利嗪溶液治疗男性雄激素性秃发的临床疗效观察[J].医学美学美容,2024,33(12):35-38.

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  • 在线发布日期: 2024-07-15