Objective To explore the effect of multidisciplinary collaborative nursing mode on incision healing and aesthetics of cesarean section patients. Methods A total of 92 primiparas who underwent cesarean section in our hospital from September 2022 to May 2023 were randomly divided into control group and study group, with 46 cases in each group. The control group was given routine perioperative nursing, while the study group was given multidisciplinary collaborative nursing mode. The scar condition, incision healing grade, pain degree, aesthetic satisfaction degree of surgical incision and aesthetic degree of scar were compared between the two groups. Results The thickness and width of scar in the study group were smaller than those in the control group (P <0.05). The proportion of grade A healing in the study group was 84.78%, which was higher than 50.00% in the control group (P <0.05). The VAS score of the study group was lower than that of the control group at 3 days after operation (P <0.05). The aesthetic satisfaction scores of surgical incision on the day after operation and 15 days after operation in the study group were higher than those in the control group (P <0.05). The PSAS and OSAS scores of the study group were lower than those of the control group (P <0.05). Conclusion The application of multidisciplinary collaborative nursing model intervention in cesarean section patients can promote the healing of maternal surgical incision, which is conducive to scar desalination, reduce postoperative incision pain and improve their quality of life.