Objective To explore the effect of antibiotic bone cement filling technology combined with autologous plateletrich plasma on repairing chronic wounds and the quality of life. Methods A total of 70 patients who received chronic wound repair in our hospital from April 2023 to April 2024 were selected as the research objects. They were divided into control group and observation group by random number table method, with 35 patients in each group. The control group was treated with autologous platelet-rich plasma, and the observation group was treated with antibiotic bone cement filling technique combined with autologous platelet-rich plasma. The clinical related indexes, repair effect, quality of life, granulation maturation rate and treatment satisfaction were compared between the two groups. Results The wound healing time of the observation group was shorter than that of the control group, and the wound reduction rate and granulation tissue growth thickness were higher than those of the control group (P <0.05). The total effective rate of wound repair in the observation group was 94.29%, which was higher than 80.00% in the control group (P <0.05). The scores of physiological function, psychological function, social function and vitality in the observation group were higher than those in the control group (P <0.05). The granulation maturation rate of the observation group was 77.14%, which was higher than 54.29% of the control group (P <0.05). The treatment satisfaction of the observation group was 97.14%, which was higher than 85.71% of the control group (P <0.05). Conclusion Antibiotic bone cement filling combined with autologous platelet -rich plasma is effective in the treatment of chronic wounds, which can promote the growth and maturation of granulation tissue, accelerate wound healing, and improve the quality of life and treatment satisfac tion of patients. It is worthy of clinical application.