Objective To explore the effect of Vaseline gauze+autologous platelet-rich plasma (PRP) coverage in patients after replantation of amputated finger. Methods A total of 59 patients who underwent replantation of amputated finger in our hospital from March 2022 to June 2023 were selected as the research objects. According to different treatment methods, they were divided into control group (n =29) and experimental group (n =29). The control group used Vaseline gauze to cover the wound, and the experimental group used Vaseline gauze+PRP to cover the wound. The wound healing, pain degree, recovery effect and adverse reactions were compared between the two groups. Results The wound healing time of the experimental group was (18.73±2.90)d, which was shorter than (25.68±1.89)d of the control group (P <0.05). The wound healing rate of the experimental group was (70.10±6.83)%, which was higher than (53.79±6.12)% of the control group (P <0.05). After treatment, the VAS score of the experimental group was (3.90±0.75)scores, which was lower than (2.90±0.80)scores of the control group (P <0.05). The excellent and good rate of recovery in the experimental group was 100.00%, which was higher than 96.55% in the control group (P <0.05). The incidence of adverse reactions in the experimental group was 0, which was lower than 3.45% in the control group, but the difference was not statistically significant (P >0.05). Conclusion The application of PRP covering Vaseline gauze to repair wounds in patients after replantation of amputated finger has a definite effect, which can improve the speed of wound healing, improve the degree of pain, and reduce the incidence of adverse reactions. It is worthy of clinical application.