Objective To explore the effect of comprehensive nursing intervention in laser treatment of moderate to severe acne in women. Methods A total of 80 patients with moderate to severe acne admitted to our hospital from January 2022 to January 2023 were selected as the research objects. They were divided into control group and analysis group by random sampling method, with 40 patients in each group. Both groups were treated with laser therapy. On this basis, the control group was given routine nursing intervention, and the analysis group was given comprehensive nursing intervention. The adverse reaction rate, nursing satisfaction, quality of life, emotional state, physical and mental state were compared between the two groups. Results The incidence of adverse reactions in the analysis group was 10.00%, which was lower than 27.50% in the control group (P <0.05). The nursing satisfaction of the analysis group was 97.50%, which was higher than 75.00% of the control group (P <0.05). The SF- 12 score and positive coping style score of quality of life after nursing in the analysis group were higher than those in the control group, and the scores of hospital anxiety and depression scale and negative coping style were lower than those in the control group (P <0.05). Conclusion Comprehensive nursing for patients with moderate to severe acne has a good effect, which can reduce the occurrence of adverse reactions, improve patient satisfaction, reduce emotional reactions such as anxiety and depression, improve patients' effective coping ability, and then improve patients' quality of life.