Objective To explore the application effect of embedding technique combined with sodium hyaluronate solution for injection in the treatment of facial rejuvenation. Methods A total of 107 patients who received facial rejuvenation treatment in Suzhou Xinmao Medical Cosmetology Hospital from January to December 2023 were selected as the research objects. According to different treatment methods, they were divided into control group (n =40) and observation group (n =67). The control group was treated with embedding technique, and the observation group was treated with embedding technique combined with sodium hyaluronate solution injection. The facial rejuvenation effect, adverse reactions, facial contour score and cosmetic satisfaction score were compared between the two groups. Results The total improvement rate of the observation group was 91.04%, which was higher than 77.50% of the control group (P <0.05). The incidence of adverse reactions in the observation group was 14.93%, which was higher than 10.00% in the control group, but the difference was not statistically significant (P >0.05). The facial contour score of the observation group was higher than that of the control group after treatment (P <0.05). The cosmetic satisfaction score of the observation group was (8.68±0.81)scores, which was higher than (8.12±0.75)scores of the control group (P <0.05). Conclusion The application effect of embedding technique combined with sodium hyaluronate solution for injection in the treatment of facial rejuvenation is definite, which can effectively improve the facial contour and promote facial rejuvenation. Meanwhile, the application safety is good, the incidence of postoperative complications is low, and the patient satisfaction is high.