Objective To explore the clinical efficacy of concentrated growth factor combined with low-energy laser irradiation in patients with androgenetic alopecia. Methods A total of 60 patients with androgenetic alopecia admitted to Heilongjiang Provincial Hospital from July 2023 to January 2024 were selected as the research objects, and they were divided into control group and observation group by random number table method, with 30 patients in each group. The control group was treated with low-energy laser irradiation, and the observation group was treated with low-energy laser irradiation combined with concentrated growth factor injection. The scalp symptom score, hair mirror data, clinical efficacy and adverse reactions were compared between the two groups. Results The scalp symptom score of the two groups after treatment was lower than that before treatment, and that of the observation group was lower than that of the control group, the difference was statistically significant (P <0.05). After treatment, the hair diameter and hair density of the two groups were better than those before treatment, and those of the observation group were better than those of the control group, the differences were statistically significant (P <0.05). The total effective rate of the observation group was 83.33% (25/30), which was higher than 70.00% (21/30) of the control group, and the difference was statistically significant (P <0.05). The incidence of adverse reactions in the observation group was 20.00% (6/30), which was slightly higher than 16.67% (5/30) in the control group, but the difference was not statistically significant (P >0.05). Conclusion Concentrated growth factor combined with low-energy laser irradiation is effective in patients with androgenic alopecia, which can reduce the score of scalp symptoms, improve hair diameter and hair density, and has good treatment safety. It is worthy of clinical application.