Objective To investigate the effect of modified adhesive retention in oral implant restoration. Methods A total of 74 patients with dentition loss admitted to the Department of Implantology, Suzhou Stomatological Hospital from January 2023 to January 2024 were selected as the research objects. They were divided into control group and study group by random number table method, with 37 patients in each group. The control group was treated with traditional adhesive retention for oral implant restoration, and the study group was treated with modified adhesive retention for oral implant restoration. The repair effect, periodontal health level, implant function, inflammatory factor level and implant satisfaction were compared between the two groups. Results The total effective rate of repair in the study group was 97.30%, which was higher than 81.08% in the control group, and the difference was statistically significant (P <0.05). After treatment, the scores of periodontal plaque index and gingival sulcus bleeding index in the study group were higher than those in the control group, the differences were statistically significant (P <0.05). After treatment, the scores of language function, masticatory function and aesthetic function in the study group were higher than those in the control group, and the differences were statistically significant (P <0.05). After treatment, the levels of MMP-8 and IL-1 in the study group were lower than those in the control group, the differences were statistically significant (P <0.05). The planting satisfaction of the study group was higher than that of the control group, and the difference was statistically significant (P <0.05). Conclusion The application of modified adhesive retention in the treatment of oral implant restoration is more ideal, which is beneficial to improve the periodontal health level level of patients, improving their masticatory function, speech function, reducing the level of inflammatory factors, and has good aesthetics. It is worthy of clinical application.