Objective To investigate the effect of guided bone regeneration combined with delayed implantation repair in patients with dentition defect in aesthetic area. Methods A total of 78 patients with dentition defect in aesthetic area admitted to the Department of Stomatology, Hai'an People's Hospital from June 2022 to December 2023 were randomly divided into control group and study group, with 39 patients in each group. The control group underwent routine treatment after tooth extraction, and the study group underwent guided bone regeneration after tooth extraction. Both groups underwent delayed implantation repair. The implant effect, alveolar bone condition, aesthetic effect and complications were compared between the two groups. Results The total effective rate of planting in the study group was 92.31%, which was higher than 74.36% in the control group (P<0.05). The height, width and bone mineral density of alveolar bone in the study group were higher than those in the control group at 3 months after operation (P<0.05). The scores of PES and WES in the study group were higher than those in the control group (P<0.05). The incidence of complications in the study group was 7.69%, which was lower than 30.77% in the control group (P<0.05). Conclusion The application of guided bone regeneration combined with delayed implantation repair in patients with dentition defect in aesthetic area is effective, which can not only improve the success rate of implantation, but also effectively improve the alveolar bone condition of patients, optimize the aesthetic effect, and help to reduce the incidence of complications.