Objective To analyze the aesthetic effect of combined orthodontic and restorative treatment for patients with dentition defect with dental deformity. Methods From January 2022 to January 2024, 60 patients with dentition defect and dentofacial deformity were randomly divided into experimental group (n =30) and reference group (n =30). The reference group was treated with restorative treatment, and the experimental group was treated with combined orthodontic and restorative treatment. The aesthetic effect, tooth function and satisfaction of the two groups were compared. Results The proportion of neatly arranged teeth, anterior teeth coverage and posterior teeth occlusion in the experimental group was higher than that in the reference group (P <0.05). After treatment, the scores of dental function (language function, masticatory function, swallowing function) in the experimental group were higher than those in the reference group (P <0.05). The satisfaction rate of the experimental group was 96.67%, which was higher than 66.67% of the reference group (P <0.05). Conclusion Combined orthodontic and restorative treatment can improve the aesthetics and dental function of patients with dentition defect and dental deformity, and the patient satisfaction is high.