Objective To explore the effect of digital intraoral scanning technology combined with model-made implant guide on the implant effect of patients with tooth loss. Methods A total of 100 patients with tooth loss admitted to Beijing First and Best Dental Co., Ltd. from March 2021 to February 2022 were selected as the research objects. They were divided into control group and observation group by random number table method, with 50 patients in each group. The control group was treated with conventional implant restoration, and the observation group was treated with digital intraoral scanning technology combined with model-made implant guide restoration. The three-dimensional position deviation value, masticatory efficiency, quality of life, implant success rate, satisfaction and complications were compared between the two groups. Results The top, root tip, depth and angle deviation values of the observation group were better than those of the control group, and the differences were statistically significant (P <0.05). The masticatory efficiency after repair in the observation group was (85.02±4.53)%, which was higher than (82.63±4.27)% in the control group, and the difference was statistically significant (P <0.05). The quality of life score of the observation group after repair was better than that of the control group, and the difference was statistically significant (P <0.05). The success rate of implantation in the observation group was 98.00%, which was higher than 86.00% in the control group, and the difference was statistically significant (P <0.05). The satisfaction rate of the observation group was 94.00%, which was higher than 80.00% of the control group, and the difference was statistically significant (P <0.05). The incidence of complications in the observation group was 2.00%,which was lower than 14.00% in the control group, the difference was statistically significant (P <0.05). Conclusion The effect of digital intraoral scanning technology combined with model-made implant guide in the oral restoration of patients with tooth loss is ideal, which can improve the three-dimensional position deviation of patients, improve the masticatory efficiency of patients, improve the success rate of planting, reduce the incidence of complications, and then improve patient satisfaction. It is worthy of clinical application.