Abstract:Objective To analyze the clinical effect of pulsed dye laser combined with CO2 fractional laser in the treatment of hypertrophic scars. Methods A total of 64 patients with hypertrophic scar admitted to our hospital from January to December 2023 were selected as the research objects. According to different treatment methods, they were divided into control group and observation group, with 32 patients in each group. The control group was treated with CO2 fractional laser, and the observation group was treated with pulsed dye laser combined with CO2 fractional laser. The clinical efficacy, scar thickness, area, pain score, pruritus score and adverse reactions were compared between the two groups. Results The total effective rate of treatment in the observation group was 96.88 %, which was higher than 75.00 % in the control group (P <0.05). After treatment, the scar thickness, area, pain score and pruritus score of the observation group were lower than those of the control group (P <0.05). The incidence of adverse reactions in the observation group was 15.63 %, which was higher than 12.50 % in the control group, but the difference was not statistically significant (P >0.05). Conclusion The effect of pulsed dye laser combined with CO2 fractional laser in the treatment of hypertrophic scar is better than that of CO2 fractional laser. It is helpful to reduce the scar area, improve the skin appearance, reduce the pain and itching, and will not increase the incidence of adverse reactions. It is worthy of clinical application.