强脉冲光和CO2点阵激光治疗面部光老化效果及安全性的Meta分析
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吴芳晓(1993.10-),女,广西桂林人,硕士,主治医师,主要从事面部年轻化、脂肪干细胞等研究

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R751


Meta-analysis of the Efficacy and Safety of Intensive Pulsed Light and CO2 Fractional Laser in the Treatment of Facial Skin Photoage
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    摘要:

    目的 评价面部皮肤光老化患者采用强脉冲光和CO2点阵激光治疗的临床疗效。方法 通过计算机 检索中国知网、万方、维普、PubMed、Cochrane、Embase、Web of Science数据库并收集关于强脉冲光和 CO2点阵激光治疗面部皮肤光老化的随机对照试验(RCT),检索时限至2024年8月。由2位研究者独立进 行文献筛选、资料提取,利用RevMan 5.3对结局指标进行Meta分析,并进行发表偏倚检验。结果 最终纳 入10项RCTs,共969例患者。Meta分析显示,CO2点阵激光治疗面部皮肤光老化的总有效率优于强脉冲光 [RR =1.14,95%CI(1.07,1.21),Z =4.04,P <0.0001],不良反应发生率低于强脉冲光[RR =0.51,95%CI (0.32,0.79),Z =2.99,P =0.003]。结论 CO2点阵激光对面部皮肤光老化的疗效优于强脉冲光,且不良反 应发生少。

    Abstract:

    Objective To evaluate the clinical efficacy of intensive pulsed light and CO2 fractional laser in the treatment of facial skin photoage. Methods The databases of CNKI, Wanfang, VIP, PubMed, Cochrane, Embase and Web of Science were searched by computer to collect randomized controlled trials (RCTs) of intensive pulsed light and CO2 fractional laser in the treatment of facial skin photoage. The retrieval time was limited to August 2024. Two researchers independently screened the literature and extracted the data. Meta-analysis of the outcome indicators was performed using RevMan 5.3, and the publication bias test was performed. Results A total of 10 RCTs involving 969 patients were included. Meta-analysis showed that the total effective rate of CO2 fractional laser in the treatment of facial skin photoage was better than that of intensive pulsed light [RR =1.14, 95%CI (1.07, 1.21), Z =4.04, P <0.0001], and the incidence of adverse reactions was lower than that of intense pulsed light [RR =0.51, 95%CI (0.32, 0.79), Z =2.99, P =0.003]. Conclusion The curative effect of CO2 fractional laser on facial skin photoage is better than that of intensive pulsed light, and the adverse reactions are less.

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吴芳晓.强脉冲光和CO2点阵激光治疗面部光老化效果及安全性的Meta分析[J].医学美学美容,2024,33(21):25-28.

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  • 在线发布日期: 2024-11-22