Objective To analyze the clinical effect of vacuum sealing drainage in patients with burn and plastic surgery and its effect on wound healing. Methods A total of 60 patients who underwent burn and plastic surgery in the Affiliated Hospital of Nankai University from June 2022 to June 2023 were randomly divided into reference group and analysis group, with 30 patients in each group. The reference group was treated with routine surgery, and the analysis group was treated with vacuum sealing drainage on the basis of the reference group. The wound bacterial count, wound healing time, positive rate of bacterial culture, wound healing rate, one-time success rate of skin grafting, scar hyperplasia score, treatment satisfaction score and treatment cost were compared between the two groups. Results The number of bacteria in the analysis group was lower than that in the reference group at 15 and 30 days after operation (P <0.05). The wound healing time of the analysis group was shorter than that of the reference group (P <0.05). The positive rate of bacterial culture, wound healing rate and one-time success rate of skin grafting in the analysis group were better than those in the reference group (P <0.05). The scar hyperplasia score and treatment cost of the analysis group were lower than those of the reference group, and the treatment satisfaction score was higher than that of the reference group (P <0.05). Conclusion Vacuum sealing drainage can reduce the postoperative infection rate of patients with burn and plastic surgery, improve the success rate of skin grafting, prevent scar hyperplasia, shorten the wound healing time, promote rapid wound healing, thus reducing the treatment cost, and has positive significance for improving patient satisfaction.