Objective To investigate the effect of invisible appliances in the treatment of skeletal class Ⅱ malocclusion. Methods A total of 68 adolescent patients with skeletal Class Ⅱ malocclusion admitted to our hospital from March 2020 to April 2022 were selected as the research objects. They were divided into conventional group and experimental group by random number table method, with 34 patients in each group. The conventional group was treated with traditional orthodontic treatment, and the experimental group was treated with invisible appliance. The temporomandibular joint index, occlusal function, temporomandibular joint space index and satisfaction were compared between the two groups. Results After treatment, the short axis length of condyle and the upper height of condyle in the experimental group were higher than those in the conventional group (P <0.05), but there was no significant difference in the inclination angle, socket depth, long axis length of the ankle process, and anklemedian distance between the two groups after treatment (P >0.05). There was no significant difference in R value, anterior space of temporomandibular joint, posterior space of temporomandibular joint and superior space of temporomandibular joint between the two groups (P >0.05). The satisfaction rate of the experimental group was 97.06%, which was higher than 79.41% of the conventional group (P <0.05). Conclusion Invisible appliance is effective in the treatment of skeletal class Ⅱmalocclusion in adolescents. It can effectively improve the short axis length of condyle and the upper height of condyle, which is conducive to promoting the normal development of jaw and the recovery of occlusal function. Meanwhile, the patient satisfaction is high, which is worthy of clinical application.