Objective To explore the effect of micro-implant anchorage assisted maxillary molar distalization in the treatment of Angle class Ⅱ malocclusion with mild to moderate crowding. Methods From January 2020 to December 2021, 86 patients with Angle class Ⅱ malocclusion and mild to moderate crowding admitted to Hanbin Mingli Stomatological Clinic were selected as the research objects, and they were randomly divided into control group and observation group, with 43 patients in each group. The control group was treated with the whole distalization of maxillary molars, and the observation group was treated with microimplant anchorage to assist the whole distalization of maxillary molars. The treatment effect, adverse reactions and treatment compliance of the two groups were compared. Results The total effective rate of correction in the observation group was 95.35%, which was higher than 76.74% in the control group (P <0.05). The incidence of adverse reactions in the observation group was 4.65%, which was lower than 23.26% in the control group (P <0.05). The treatment compliance of the observation group was 95.35%, which was higher than 70.09% of the control group (P <0.05). Conclusion The effect of micro-implant anchorage assisted maxillary molar distalization in the treatment of Angle class Ⅱ malocclusion with mild to moderate crowding is good, which can resist the reaction force generated in the process of molar distalization, realize the overall distalization of molars, and maintain a good occlusal relationship. Meanwhile, it is helpful to improve the treatment compliance and reduce the occurrence of adverse reactions, which is worthy of clinical application.