Objective: To analyze the clinical efficacy of poly-L-lactic acid (PLLA) injection therapy in the improvement of orbital aging and its impact on patient satisfaction, and to provide evidence-based basis for the formulation of anti-aging treatment plans in the orbital area. Method: Two hundred patients who received anti-aging treatment in the orbital area in our hospital from January 2022 to January 2025 were selected and all were treated with stratified injection of poly-L-lactic acid. The orbital Aging Score Scale (OAS) was used to evaluate the appearance improvement effect, satisfaction and incidence of adverse reactions of the patients before treatment and at 1 month, 3 months and 6 months after treatment, respectively. Result: All 200 patients were able to adhere to the 6-month follow-up, and no dropout cases were found. The OAS scores at 1 month, 3 months and 6 months after treatment were lower than those before treatment (P < 0.05). Six months after the treatment, the satisfaction rates of the patients with the improvement of orbital area contour, skin elasticity and wrinkles were 92.0% (184/200), 89.5% (179/200), 88.0% (176/200), and the total satisfaction rate was 87.5% (175/200). The adverse reaction rate during the treatment was 12 cases (6.0%), including 8 cases of local swelling and 4 cases of mild bruising. All of them relieved spontaneously within 1-2 weeks, and no serious adverse reactions occurred. Conclusion: The application of poly-L-lactic acid injection therapy can effectively improve the aging appearance of the orbital area in patients, and the effect becomes more stable with the extension of treatment time. The satisfaction of patients is relatively high, and the safety is good.