Objective To explore the effect of invisible orthodontic appliances on facial aesthetics and psychological status in patients with dental malalignment. Methods A total of 60 patients with dental malalignment admitted to our hospital from January to October 2023 were selected, and they were divided into the control group and the observation group by the random number table method, with 30 patients in each group. The control group was treated with fixed appliances, and the observation group was treated with invisible orthodontic appliances . The cephalometric parameters, facial aesthetics, psychological status, initial treatment pain intensity, complication rate and satisfaction were compared between the two groups. Results After treatment, the FMIA, U1-L1, upper lip E-line distance and lower lip E-line distance in the observation group were better than those in the control group, the AC-IOTN, SCL-90 scores and VAS scores on the 3rd and 7th days of treatment were lower than those in the control group (P <0.05). The incidence of complications in the observation group (3.33%) was lower than that in the control group (20.00%), and the satisfaction was higher than that in the control group (P <0.05). Conclusion Invisible orthodontic appliances can effectively correct dental malalignment, improve patients' facial aesthetics and psychological status, enhance satisfaction, and have high treatment safety.