【】Objective:To explore the clinical efficacy of vacuum sealing drainage combined with adjacent flap transposition in the repair of pressure injuries.Methods:A total of 60 patients with pressure injuries admitted to our hospital from January 2023 to July 2025 were selected and divided into two groups by drawing lots, with 30 cases in each group. The control group was treated with vacuum sealing drainage alone, while the observation group was treated with vacuum sealing drainage combined with adjacent flap transposition. The therapeutic efficacy, changes in wound area and depth, wound healing time, wound skin color recovery time, wound secretion disappearance time, as well as pain degree and sleep quality scores were compared between the two groups.Results:The treatment success rate of the observation group was significantly higher than that of the control group (p＜0.05). Before treatment, there were no significant differences in wound area and depth between the two groups (p＞0.05). After treatment, the wound area was reduced and the depth was shallower in both groups, and the improvements in the observation group were more significant than those in the control group (p＜0.05). The wound healing time, wound skin color recovery time and wound secretion disappearance time of the observation group were all shorter than those of the control group (p＜0.05). Before treatment, there were no significant differences in Numerical Rating Scale (NRS) scores and Pittsburgh Sleep Quality Index (PSQI) scores between the two groups (p＞0.05). After treatment, the NRS and PSQI scores of both groups decreased, and the scores of the observation group were lower than those of the control group (p＜0.05).Conclusion:Vacuum sealing drainage combined with adjacent flap transposition has an ideal effect in repairing pressure injuries. It can greatly promote wound healing, thereby shortening the wound healing time, helping to relieve wound pain and improving the sleep quality of patients.