Objective: To explore the clinical effect of concentrated growth factor (CGF) on tissue regeneration and gingival repair in patients undergoing oral implant restoration. Methods: Sixty patients with posterior teeth implant areas that could not be routinely implanted from October 2023 to October 2024 who were treated in our hospital were selected as the research subjects. They were divided into the control group and the observation group. Both groups underwent implant surgery. The control group was treated with Osteon II bone powder + Collagen Membrane, while the observation group was treated with Osteon II bone powder + CGF membrane + Collagen Membrane. The repair effects of the two groups were compared. The patients were examined before the operation, immediately after the operation, and at regular intervals after the operation. The healing of the soft tissue flap, infection, and repair conditions of the two groups were checked. The regeneration and repair of bone tissue were evaluated by cone-beam CT (CBCT). The width of keratinized gingiva was measured to evaluate the repair effect of soft tissue. Results: There was no significant difference in the VAS score 24 hours after the operation and the implant survival rate 3 months after the operation between the two groups (P > 0.05). The healing of the mucosa in the observation group was significantly better than that in the control group 1 week after the operation (P < 0.05). The horizontal and vertical bone volume of the implants in the observation group was significantly greater than that in the control group at 6 and 12 months after the operation, and the differences were statistically significant (P < 0.05). The bone tissue repair rate in the observation group at 6, 9, and 12 months after the operation was significantly different from that in the control group (P < 0.05). The width of keratinized gingiva in the observation group at 6 and 12 months after the operation was (3.47 ± 1.14) and (3.22 ± 0.97) mm, respectively, which was significantly greater than that in the control group (2.85 ± 0.97) and (2.47 ± 0.99) mm, and the differences were statistically significant (P < 0.05). Conclusion: The application of modified GBR surgery + CGF in the posterior teeth area can enhance the osteogenic ability and the regeneration ability of oral soft tissue, and is worthy of clinical promotion and application.