Objective:To explore the application of adsorption denture in edentulous patients and its influence on OHIP-14 score. Methods: A total of 73 patients with complete edentulism admitted to our hospital from January 2022 to December 2025 were enrolled and divided into the control group (36 cases) and the observation group (37 cases) by the ball drawing method. The control group received traditional complete denture restoration, while the observation group underwent implant-supported denture restoration. The oral health impact, satisfaction and incidence of complications were compared between the two groups.Results: Before restoration, there were no significant differences in baseline data and OHIP-14 scores of all dimensions between the two groups (P>0.05). After restoration, the OHIP-14 scores of all seven dimensions in both groups decreased significantly (intra-group P<0.001), and the scores of all dimensions in the observation group were significantly lower than those in the control group (P<0.001). The scores of all satisfaction dimensions including comfort and retention function in the observation group were higher than those in the control group (P<0.001). The total incidence of complications within 3 months in the observation group (24.32%) was significantly lower than that in the control group (47.22%) (χ2=4.172, P=0.041). Conclusion: Implant-supported denture restoration, based on functional impression and optimized prosthesis design, can more significantly improve the oral health-related quality of life in patients with complete edentulism, enhance satisfaction in core dimensions and reduce the risk of postoperative complications, with prominent clinical application value and worthy of promotion.