Objective: To evaluate the clinical efficacy of platelet-rich plasma (PRP) in the treatment of melasma and its effects on inflammation- and pigment metabolism–related factors.
Methods: A total of 200 patients with melasma treated from January 2024 to November 2025 were randomly divided into a control group and an observation group (n=100 each). The control group received conventional aesthetic skin therapy, while the observation group was additionally treated with PRP. Changes in melasma area and severity index (MASI), skin pigmentation, skin texture, and patient satisfaction were compared between the two groups.
Results: After treatment, MASI scores in both groups decreased significantly (P<0.05), with lower scores in the observation group (P<0.05). The observation group showed greater improvement in pigmentation, skin glossiness, and skin texture (P<0.05). Patient satisfaction was also significantly higher in the observation group (P<0.05).
Conclusion: PRP combined with conventional aesthetic therapy effectively improves pigmentation and skin texture in melasma patients, enhances overall cosmetic outcomes, and increases patient satisfaction.