基于MRD1恢复轨迹的CFS悬吊术矫正先天性上睑下垂疗效预测模型构建
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广西壮族自治区民族医院医疗美容科 广西梧州

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Construction of a predictive model for the efficacy of CFS suspension surgery in correcting congenital ptosis based on the recovery trajectory of MRD1
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    摘要:

    目的 构建基于上睑缘反光点距离1(MRD1)恢复轨迹的联合筋膜鞘(CFS)悬吊术疗效预测模型。方法 回顾性纳入2022年6月至2025年6月接受CFS悬吊术的单纯性先天性上睑下垂患者80例(80眼),随访6个月。按术前MRD1分为中度32例和重度48例,按6个月MRD1、双眼对称度、睑缘弧度及再矫正情况分为疗效良好组64例和欠佳组16例。记录术前及术后1周、1、3、6个月MRD1,计算阶段回落幅度;采用线性混合模型、Logistic回归、ROC、Bootstrap校准及决策曲线评价模型。结果 两组MRD1术后1周均升高,良好组随后稳定,欠佳组1~3个月明显回落,时间×分组交互效应显著(P<0.001)。重度组1~3个月回落幅度高于中度组[P<0.001],6个月疗效欠佳率亦较高(P=0.012)。术前MRD1、提上睑肌功能、术后1个月MRD1达标及1~3个月回落>0.5 mm为独立影响因素。轨迹增强模型AUC为0.891(95%CI:0.812~0.970),Bootstrap校正AUC为0.874。结论 CFS悬吊术后1~3个月MRD1持续回落,可提示固定与组织黏附不足。

    Abstract:

    Objective To develop a model using the recovery trajectory of margin reflex distance 1 (MRD1) to predict outcomes after conjoint fascial sheath (CFS) suspension for congenital ptosis. Methods Eighty patients (80 eyes) treated from January 2023 to January 2026 were retrospectively included and followed for 6 months. According to preoperative MRD1, 32 cases were moderate and 48 were severe; 64 had a good outcome and 16 a poor outcome. MRD1 was measured before surgery and at 1 week, 1, 3 and 6 months. A linear mixed model, logistic regression, ROC analysis, Bootstrap calibration and decision curve analysis were used. Results MRD1 increased at 1 week in both groups. The good-outcome group remained stable, whereas the poor-outcome group showed marked regression from 1 to 3 months (interaction P<0.001). Regression was greater in severe cases (P<0.001), with a higher poor-outcome rate (P=0.012). Preoperative MRD1, levator function, MRD1 ≥3.0 mm at 1 month and regression >0.5 mm from 1 to 3 months were independent predictors. The trajectory-enhanced model achieved an AUC of 0.891 (95%CI: 0.812-0.970), and the Bootstrap-corrected AUC was 0.874. Conclusion Persistent MRD1 regression from 1 to 3 months indicates insufficient fixation or tissue adhesion.

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  • 收稿日期:2026-07-28
  • 最后修改日期:2026-09-03
  • 录用日期:2026-09-03
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