Objective To explore the improvement effect of digital-assisted orthodontic camouflage therapy on soft tissue profile indicators in adults with mild to moderate skeletal class Ⅱ malocclusion. Methods A total of 98 adult patients with mild to moderate skeletal class Ⅱ malocclusion treated in our hospital from August 2021 to November 2023 were selected, and they were divided into the control group and the observation group by the random number table method, with 49 patients in each group. The control group received conventional ffxed orthodontic camouffage therapy, and the observation group received digital-assisted orthodontic camouffage therapy. The hard tissue indicators, soft tissue proffle indicators, clinical efffcacy, proffle satisfaction and treatment duration were compared between the two groups. Results After treatment, the ANB and U1-SN in the observation group were lower than those in the control group, and the SNB was higher than that in the control group (P<0.05). After treatment, the upper lip protrusion and lower lip protrusion in the observation group were lower than those in the control group, and the Z angle was higher than that in the control group (P<0.05). The total effective rate of treatment in the observation group (95.92%) was higher than that in the control group (81.63%) (P<0.05). The proffle satisfaction score of the observation group was higher than that of the control group, and the treatment duration was shorter than that of the control group (P<0.05). Conclusion Digital-assisted orthodontic camouflage therapy can improve facial profile more accurately and efficiently in adults with mild to moderate skeletal class Ⅱ malocclusion, enhance treatment effect and patient satisfaction, and shorten treatment duration.