Objective To compare the effect of ciprofol and propofol in anesthesia for facial plastic surgery and its inffuence on injection pain rate and comfort. Methods A total of 86 patients who underwent facial plastic surgery in Jiangsu Province Hospital of TCM from March 2023 to March 2026 were selected, and they were divided into group A and group B by the random number table method, with 43 patients in each group. Group A was given propofol anesthesia, and group B was given ciprofol anesthesia. The hemodynamic parameters, anesthesia onset time, post-anesthesia care unit stay time, injection pain rate, comfort and adverse reaction rate were compared between the two groups. Results There were no signiffcant differences in MAP and HR at T0 between the two groups (P>0.05). The MAP and HR in group B at T1, T2 and T3 were lower than those in group A (P<0.05). The anesthesia onset time and post-anesthesia care unit stay time in group B were shorter than those in group A (P<0.05). The incidence of injection pain in group B was 2.33%, which was lower than 18.60% in group A (P<0.05). The BCS score in group B at 12 hours after operation was lower than that in group A (P<0.05). The incidence of adverse reactions in group B (4.65%) was lower than that in group A (23.26%) (P<0.05). Conclusion Compared with propofol, ciprofol has better efficacy in anesthesia for facial plastic surgery, which can more effectively maintain hemodynamic stability, shorten anesthesia onset and recovery time, reduce the incidence of injection pain and other adverse reactions, and improve patient comfort.