Objective To explore the application effect of cosmetic suture combined with early intervention of recombinant human epidermal growth factor (rhEGF) in facial trauma. Methods A total of 80 patients with facial trauma admitted to Shanghai Baoshan Luodian Hospital from January 2024 to March 2025 were selected, and they were divided into the control group and the observation group by the random number table method, with 40 patients in each group. The control group received cosmetic suture combined with routine dressing change, and the observation group received cosmetic suture combined with early intervention of rhEGF. The wound healing time, Vancouver Scar Scale (VSS) score, Patient and Observer Scar Assessment Scale (POSAS) score, scar width, patient satisfaction and complication rate were compared between the two groups. Results The wound healing time of the observation group was shorter than that of the control group (P<0.05). The scores of VSS in the observation group at 3, 6 and 12 months after operation were lower than those in the control group (P<0.05). At 12 months after operation, the scar width of the observation group was smaller than that of the control group, and the total POSAS score was lower than that of the control group (P<0.05). The patient satisfaction rate of the observation group (92.50%) was higher than that of the control group (72.50%) (P<0.05). The VAS satisfaction score of the observation group was higher than that of the control group (P<0.05). There was no signiffcant difference in the incidence of complications between the two groups (P>0.05). Conclusion The application of cosmetic suture combined with early intervention of rhEGF in facial trauma can shorten wound healing time, reduce scar hyperplasia, and improve patient satisfaction, without increasing the risk of complications.