Objective To analyze the effect of whole-process skin nursing on skin repair time in patients after fractional laser surgery. Methods A total of 120 patients who underwent fractional laser surgery in the First Afffliated Hospital of Guangdong Pharmaceutical University from January to October 2025 were selected as the research subjects, and they were divided into the control group and the observation group by the random number table method, with 60 patients in each group. The control group received conventional nursing, and the observation group received whole-process skin nursing on the basis of the control group. The skin repair time, facial condition and adverse reaction rate were compared between the two groups. Results The erythema duration, decrustation time and pain duration in the observation group were shorter than those in the control group (P<0.05). After intervention, the scores of skin spots, texture, pores, redness, purpura and ultraviolet pigmentation in the observation group were lower than those in the control group (P <0.05). The incidence of adverse reactions in the observation group (5.00%) was lower than that in the control group (15.00%) (P <0.05). Conclusion In the repair process after fractional laser surgery, the application of whole-process skin nursing can not only effectively shorten patients' skin repair time and improve facial skin condition, but also reduce the incidence of adverse reactions.