As the medical aesthetic industry transforms towards scientization and interdisciplinarity, there is a growing demand for compound technical talents for cosmetic optoelectronic instrument operation posts. Aiming at the existing problems of traditional cosmetic instrument application courses in medical aesthetic technology major, including solidified professional barriers, poor connection between academic certiffcates and vocational certiffcates, disconnection between practical teaching and industrial demands, and a single evaluation system, this study takes the 1+X vocational skill level certiffcate system for cosmetic optoelectronic instrument operation as the core. It integrates professional knowledge of nursing, pharmacy, Chinese pharmacy and traditional Chinese rehabilitation technology, and establishes an interdisciplinary integrated reform plan of "teaching-learning-training-assessment". By implementing the reform path of "four-dimensional deconstruction-three-level reconstruction-four-stage progression-diversiffed evaluation", this paper develops an interdisciplinary curriculum cluster with "one main body and two wings", loose-leaf textbooks and online resource platforms, and builds dual school-enterprise training carriers as well as a full-process closed-loop quality evaluation mechanism. It provides a replicable practical model for medical aesthetic majors to break disciplinary boundaries and deepen the integration of academic and vocational certiffcates.